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From the North (Lynchburg) 

Take US 29 South Business. Continue onto VA 86 South. Take the 293/West Main Street ramp.
Turn Left onto 293 North/West Main Street. At the top of the ramp turn left onto
West Main Street. West Main Street will become Main Street. Travel approximately .25 mile (.5 mile including West Main); the Museum will be on your right.

From the East (South Boston) 

Take US 58/360 West. US 58/360 West will become South Boston Road. South Boston Road will become River Street. Turn Left on Main Street (Rev. Dr. Martin Luther King Jr. Bridge). Travel approximately 1 mile, the Museum will be on your left, between Sutherlin Avenue, the First Presbyterian Church, and Holbrook Avenue, Crema & Vine. Parking is on the south side on the Museum on Magruder's Alley.

From the South (Greensboro) 

Take US 29 North. Take the VA 86 ramp toward Danville/Yanceyville. Take the ramp toward Danville. Turn Left onto VA 86 N/South Main Street. South Main Street will become Central Boulevard. Take the West Main Street ramp. At the top of the ramp turn left onto West Main Street. West Main Street will become Main Street. Travel approximately .25 mile, the museum will be on your right. The Museum is located at the top of Main Street hill between Crema & Vine and the First Presbyterian Church. Parking is on the south side of the Museum and can be accessed by turning down either Sutherlin Avenue or Holbrook Avenue.

From the West (Martinsville) 

Take US 58 East. Take the US 29/VA-86 South ramp toward Downtown/Greensboro. Take the 293/West Main Street ramp. At the top of the ramp turn left onto West Main Street. West Main Street will become Main Street. Travel approximately .25 mile (.5 mile including West Main); the museum will be on your right.